The main objective of this article is to demonstrate the impact of uncertainty on the resilience of supply chains. To achieve this task, a theoretical discourse is presented on both uncertainty and supply chain resilience. A survey is conducted among 160 supply chain managers and directors from around the world. The survey utilized the computer-assisted web interview (CAWI) method, and the results are analyzed using the Ward agglomeration method. The findings enabled a determination of the strength of uncertainty’s impact on supply chain resilience, understood through the so-called 4A formula, which combines flexibility, adaptability, resilience, and alignment. Additionally, the article discusses whether these considerations can contribute to supply chain management, particularly in supporting decision-making processes, such as the supply chain’s response to uncertainty. This study is the author’s original work and represents their contribution to the ongoing scientific discussion on the resilience (including response) of supply chains under conditions of uncertainty.